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Title: Evaluation of oxidative DNA lesions in plasma and nuclear abnormalities in erythrocytes of wild fish (Liza aurata) as an integrated approach to genotoxicity assessment
Author: Oliveira, M.
Ahmad, I.
Maria, V. L.
Ferreira, C. S. S.
Serafim, A.
Bebianno, M. J.
Pacheco, M.
Santos, M. A.
Keywords: Liza aurata
Erythrocytic nuclear abnormalities
Issue Date: 2010
Publisher: Elsevier
Abstract: Genetic lesions (8-hydroxy-2′-deoxyguanosine (8-OHdG) and erythrocytic nuclear abnormalities (ENA) were seasonally quantified in the blood of Liza aurata caught at Ria de Aveiro (Portugal), a multi-contaminated aquatic system. Thus, five critical sites were assessed and compared with a reference site (Torreira). Oxidative DNA damage was found in Gafanha (harbour-water area), Laranjo (metal-contaminated) and Vagos (contaminated with PAHs) in the spring; Rio Novo do Principe (near a former paper-mill effluent) in the autumn; Rio Novo do Principe and Vagos in the winter. ENA were higher than Torreira at VAG (spring and winter). Torreira did not display seasonal variation neither in terms of 8-OHdG or total ENA. A positive correlation between 8-OHdG and ENA was found, suggesting oxidative stress as a mechanism involved in the formation of ENA. This study clearly demonstrates the presence of DNA-damaging substances in Ria de Aveiro and recommends the use of 8-OHdG and ENA as biomarkers of environmental contamination.
Peer review: yes
DOI: 10.1016/j.mrgentox.2010.08.003
ISSN: 1383-5718
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