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Title: L-Asparaginase
Author: Tavares, Ana Paula
Nunes, João C. F.
Cristóvão, Raquel
Freire, Mara
Santos-Ebinuma, Valéria
Faria, Joaquim Luís
Silva, Cláudia
Keywords: L-Asparaginase
Confinement strategies
Therapeutic agents
Acrylamide mitigation
Issue Date: 2021
Publisher: MDPI
Abstract: L-Asparaginase (ASNase, EC is a tetrameric aminohydrolase enzyme that catalyses the hydrolysis of the amino acid L-Asparagine into ammonia and L-aspartic acid. ASNase is present in different organisms such as bacteria, fungi, plant tissues and algae. ASNase is used in the pharmaceutical field as an anticancer drug for the treatment of acute lymphoblastic leukemia (ALL) and other malignant diseases such as Hodgkin’s disease. In the food sector, ASNase is used to prevent the formation of acrylamide, a toxic compound formed when starch-rich foods are cooked at temperatures above 100 °C. ASNase can also be used as a biosensor for the detection of L-asparagine levels.
Peer review: yes
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Appears in Collections:CICECO - Artigos

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