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Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/28509
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dc.contributor.authorBjorge, Isabel M.pt_PT
dc.contributor.authorChoi, Insung S.pt_PT
dc.contributor.authorCorreia, Clara R.pt_PT
dc.contributor.authorMano, João F.pt_PT
dc.date.accessioned2020-05-15T09:59:18Z-
dc.date.issued2019-09-21-
dc.identifier.issn2040-3364pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/28509-
dc.description.abstractGrooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.pt_PT
dc.language.isoengpt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationPTDC/BTM-MAT/31064/2017pt_PT
dc.relationUID/CTM/50011/2019pt_PT
dc.relationMSIP 2012R1A3A2026403pt_PT
dc.relationSFRH/BD/129224/2017pt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/669858/EUpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell Differentiationpt_PT
dc.subjectOsteogenesispt_PT
dc.subjectMicroparticlespt_PT
dc.subjectTopographypt_PT
dc.subjectBottom-uppt_PT
dc.titleNanogrooved microdiscs for bottom-up modulation of osteogenic differentiationpt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage16214pt_PT
degois.publication.issue35pt_PT
degois.publication.lastPage16221pt_PT
degois.publication.titleNanoscalept_PT
degois.publication.volume11pt_PT
dc.date.embargo2020-09-21-
dc.relation.publisherversionhttps://pubs.rsc.org/--/content/articlelanding/2019/nr/c9nr06267j/unauth#!divAbstractpt_PT
dc.identifier.doi10.1039/c9nr06267jpt_PT
dc.identifier.essn2040-3372pt_PT
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