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Title: An easy synthetic access to new pyrazole spiro derivatives from 3-amino-1-phenyl-2-pyrazolin-5-one
Author: Zaiter, Jamila
Achibat, Hanane
Amiri, Ouafa
Hafid, Abderrafia
Khouili, Mostafa
Rakib, El Mostapha
Neves, Claudia M. B.
Neves, Maria Graca P. M. S.
Silva, Artur M. S.
Cavaleiro, Jose A. S.
Paz, Filipe A. Almeida
Faustino, Maria Amparo F.
Issue Date: 2015
Abstract: Pyrazole and pyrazolone moieties have shown important biological activities. For this reason, the synthesis of new derivatives has attracted interest from the scientific community. Herein we report the formation of two unexpected spiro compounds containing pyrazole moieties using a tandem process involving the initial condensation of 3-amino-1-phenyl-2-pyrazolin-5-one with benzaldehyde followed by dimerization.
Peer review: yes
DOI: 10.1039/c5nj01306b
ISSN: 1144-0546
Publisher Version: 10.1039/c5nj01306b
Appears in Collections:CICECO - Artigos

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