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http://hdl.handle.net/10773/20399
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DC Field | Value | Language |
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dc.contributor.author | Perez, Bianca | pt |
dc.contributor.author | Teixeira, Catia | pt |
dc.contributor.author | Gomes, Ana S. | pt |
dc.contributor.author | Albuquerque, Ines S. | pt |
dc.contributor.author | Gut, Jiri | pt |
dc.contributor.author | Rosenthal, Philip J. | pt |
dc.contributor.author | Prudencio, Miguel | pt |
dc.contributor.author | Gomes, Paula | pt |
dc.date.accessioned | 2017-12-07T19:45:50Z | - |
dc.date.issued | 2013 | pt |
dc.identifier.issn | 0960-894X | pt |
dc.identifier.uri | http://hdl.handle.net/10773/20399 | - |
dc.description.abstract | Novel 9-aminoacridine derivatives were synthesized by linking the heteroaromatic core to different cinnamic acids through an aminobutyl chain. The test compounds demonstrated mid-nanomolar in vitro activity against erythrocytic stages of the chloroquine-resistant W2 strain of the human malaria parasite Plasmodium falciparum. Two of the most active derivatives also showed in vitro activity against liver-stage Plasmodium berghei, with activity greater than that of the reference liver-stage antimalarial primaquine. The compounds were not toxic to human hepatoma cells at concentrations up to 5 mu M. Hence, 9-(N-cinnamoylbutyl)aminoacridines are a new class of leads for prevention and treatment of malaria. (c) 2012 Elsevier Ltd. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/116864/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/99118/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F62967%2F2009/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132936/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | RESISTANT PLASMODIUM-FALCIPARUM | pt |
dc.subject | CHLOROQUINE | pt |
dc.subject | DISCOVERY | pt |
dc.subject | LEADS | pt |
dc.title | In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 610 | pt |
degois.publication.issue | 3 | pt |
degois.publication.lastPage | 613 | pt |
degois.publication.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | pt |
degois.publication.volume | 23 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.bmcl.2012.12.032 | pt |
dc.identifier.doi | 10.1016/j.bmcl.2012.12.032 | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites_10.1016j.bmcl.2012.12.032.pdf | 293.49 kB | Adobe PDF |
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