Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/20117
Title: | Silver-containing calcium phosphate materials of marine origin with antibacterial activity |
Author: | Piccirillo, C. Pullar, R. C. Tobaldi, D. M. Lima Castro, P. M. Estevez Pintado, M. M. |
Keywords: | BETA-TRICALCIUM PHOSPHATE SUBSTITUTED HYDROXYAPATITE BIOFILM FORMATION FISH BONES BIOCOMPATIBILITY COMPOSITES COATINGS RELEASE APATITE NANOHYDROXYAPATITE |
Issue Date: | 2015 |
Publisher: | ELSEVIER SCI LTD |
Abstract: | Hydroxyapatite (Ca-10(PO4)(6)(OH)(2) - HAp) is a common material for bone replacement in artificial implants and prostheses, due to its high biocompatibility. In this work we report about the preparation of HAp-based materials of marine origin with antibacterial properties. Bones from cod fish (Gadhus morua) were treated with a dilute AgNO3 solution, to obtain HAp-containing samples with silver as a minor component. The samples were characterised by XRD, FT-IR spectroscopy and SEM, indicating the presence of HAp, beta-TCP and some metallic silver. The determination of unit cell parameters, however, indicated that the majority of silver is substituted in the beta-TCP lattice in ionic form. The antibacterial activity of these materials was tested towards both Gram-positive and Gram-negative bacterias; results showed that the material is very effective with Gram-negative strains such as Escherichia coli (inactivation rates of 99.82% and 99.999% after 2 and 5 h, respectively) and had a smaller but still significant effect on Gram-positive MRSA (91% inactivation rate). These results show the potentials of these samples as infection-resistant bone replacement materials. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20117 |
DOI: | 10.1016/j.ceramint.2015.04.116 |
ISSN: | 0272-8842 |
Publisher Version: | 10.1016/j.ceramint.2015.04.116 |
Appears in Collections: | CICECO - Artigos |
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File | Description | Size | Format | |
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Silver-containing calcium phosphate materials of marine origin with antibacterial activity_10.1016j.ceramint.2015.04.116.pdf | 392.27 kB | Adobe PDF |
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