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Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/20050
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dc.contributor.authorSoengas, Raquel G.pt
dc.contributor.authorSilva, Vera L. M.pt
dc.contributor.authorIde, Daisukept
dc.contributor.authorKato, Atsushipt
dc.contributor.authorCardoso, Susana M.pt
dc.contributor.authorAlmeida Paz, Filipe A.pt
dc.contributor.authorSilva, Artur M. S.pt
dc.date.accessioned2017-12-07T19:33:46Z-
dc.date.issued2016pt
dc.identifier.issn0040-4020pt
dc.identifier.urihttp://hdl.handle.net/10773/20050-
dc.description.abstractThe Henry-type Barbier addition of bromonitromethane to 3-formylchromone, immediately followed by acetylation and concomitant elimination to afford nitroalkenes in excellent yield and total (E)-selectivity is described. Cycloaddition of N-methylhydrazones with the obtained nitroalkenes gave the corresponding pyrazoles. Among the prepared pyrazoles, derivative 6j, which contains a catechol moiety, showed simultaneously a potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and an alpha-glucosidase inhibitory activities. (C) 2016 Elsevier Ltd. All rights reserved.pt
dc.language.isoengpt
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDpt
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147415/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147332/PTpt
dc.rightsrestrictedAccesspor
dc.subjectALPHA-GLUCOSIDASE INHIBITORSpt
dc.subjectANTIOXIDANT ACTIVITYpt
dc.subjectPYRAZOLE DERIVATIVESpt
dc.subjectMEDIATED REACTIONpt
dc.subjectAGENTSpt
dc.subjectNITROOLEFINSpt
dc.subjectIDENTIFICATIONpt
dc.subjectANTIBACTERIALpt
dc.subjectHYDRAZONESpt
dc.subjectSCAVENGERSpt
dc.titleSynthesis of 3-(2-nitrovinyl)-4H-chromones: useful scaffolds for the construction of biologically relevant 3-(pyrazol-5-yl)chromonespt
dc.typearticlept
dc.peerreviewedyespt
ua.distributioninternationalpt
degois.publication.firstPage3198pt
degois.publication.issue23pt
degois.publication.lastPage3203pt
degois.publication.titleTETRAHEDRONpt
degois.publication.volume72pt
dc.date.embargo10000-01-01-
dc.relation.publisherversion10.1016/j.tet.2016.04.042pt
dc.identifier.doi10.1016/j.tet.2016.04.042pt
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