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http://hdl.handle.net/10773/13445
Title: | CAR-modified T cells targeted to CD19 antigen for lymphocytic leukemia |
Other Titles: | Tratamento da leucemia linfocítica com CARs para o antigénio CD19 |
Author: | Bento, Rui Pedro Garcia de Oliveira |
Advisor: | Forte, Miguel Gago, Bruno Miguel Alves Fernandes do |
Keywords: | Biomedicina Leucemia Antigenes |
Defense Date: | 8-Sep-2014 |
Publisher: | Universidade de Aveiro |
Abstract: | Cellular immunotherapies, or Advanced Therapy Medicinal Products (ATMPs), are emerging as novel and specific therapeutic approaches to treat diseases, such as certain types of leukemias, which are difficult or impossible to treat with today’s biopharmaceutical products. Breakthroughs in basic, preclinical, and clinical science spanning cellular immunology, and cellprocessing technologies has allowed clinical applications of chimeric antigen receptor–based therapies. A recent example is CTL019, a lentivirus-based gene therapy for autologous T cells, acquired by Novartis in 2012 through a global alliance with the University of Pennsylvania. Although this technology is still in its infancy, clinical trials have already shown clinically significant antitumor activity in chronic lymphocytic leukemia and acute lymphocytic leukemia. Trials targeting a variety of other adult and pediatric malignancies are under way. The potential to target essentially any tumor-associated cell-surface antigen for which a monoclonal antibody can be made opens up an entirely new arena for targeted therapy of cancer. The regulatory environment for these Advanced Therapies Medicinal Products is complex and in constant evolution. Many challenges lie ahead in terms of manufacturing process, non-conventional supply chain logistics, business models, intellectual property, funding and patient access. |
Description: | Mestrado em Biomedicina Farmacêutica |
URI: | http://hdl.handle.net/10773/13445 |
Appears in Collections: | DCM - Dissertações de mestrado UA - Dissertações de mestrado |
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