Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/41858
Title: | Drug discovery based on oxygen and nitrogen (non-)heterocyclic compounds developed @LAQV-REQUIMTE/Aveiro |
Author: | Sousa, Joana L. C. Albuquerque, Hélio M. T. Silva, Artur M. S. |
Keywords: | Medicinal chemistry Drug discovery Heterocyclic compounds Polyphenols Antioxidant Anti-inflammatory Antidiabetic Anticancer Anti-Alzheimer Bioimaging |
Issue Date: | Dec-2023 |
Publisher: | MDPI |
Abstract: | Artur Silva's research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazoles, acridones, 4-quinolones) heterocyclic compounds in order to be assessed as antioxidant, anti-inflammatory, antidiabetic, and anticancer agents has been the main core work of our research interests. Additionally, the synthesis of steroid-type compounds as anti-Alzheimer drugs as well as of several chromophores as important dyes for cellular imaging broadened our research scope. In this review article, we intend to provide an enlightened appraisal of all the bioactive compounds and their biological properties that were synthesized and studied by our research group in the last two decades. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/41858 |
DOI: | 10.3390/ph16121668 |
Appears in Collections: | DQ - Artigos REQUIMTE - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Pharmaceuticals 2023, 16, 1668.pdf | 6.91 MB | Adobe PDF | View/Open |
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