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http://hdl.handle.net/10773/29389
Title: | Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
Author: | Direito, Inês Fardilha, Margarida Helguero, Luisa A |
Issue Date: | Feb-2019 |
Publisher: | Oxford University Press (OUP) |
Abstract: | Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/29389 |
DOI: | 10.1093/carcin/bgy182 |
ISSN: | 0143-3334 |
Appears in Collections: | IBIMED - Artigos DCM - Artigos |
Files in This Item:
File | Description | Size | Format | |
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direito2018.pdf | 1.24 MB | Adobe PDF | View/Open |
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