Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/27729
Title: | Evolution of pathogenicity and sexual reproduction in eight Candida genomes |
Author: | Butler, Geraldine Rasmussen, Matthew D. Lin, Michael F. Santos, Manuel A. S. Sakthikumar, Sharadha Munro, Carol A. Rheinbay, Esther Grabherr, Manfred Forche, Anja Reedy, Jennifer L. Agrafioti, Ino Arnaud, Martha B. Bates, Steven Brown, Alistair J. P. Brunke, Sascha Costanzo, Maria C. Fitzpatrick, David A. Groot, Piet W. J. de Harris, David Hoyer, Lois L. Hube, Bernhard Klis, Frans M. Kodira, Chinnappa Lennard, Nicola Logue, Mary E. Martin, Ronny Neiman, Aaron M. Nikolaou, Elissavet Quail, Michael A. Quinn, Janet Santos, Maria C. Schmitzberger, Florian F. Sherlock, Gavin Shah, Prachi Silverstein, Kevin A. T. Skrzypek, Marek S. Soll, David Staggs, Rodney Stansfield, Ian Stumpf, Michael P. H. Sudbery, Peter E. Srikantha, Thyagarajan Zeng, Qiandong Berman, Judith Berriman, Matthew Heitman, Joseph Gow, Neil A. R. Lorenz, Michael C Birren, Bruce W. Kellis, Manolis Cuomo, Christina A. |
Keywords: | Candida Codon Conserved sequence Diploidy Genes, Fungal Genome, Fungal Meiosis Polymorphism, Genetic Reproduction Saccharomyces Virulence Evolution, Molecular |
Issue Date: | 4-Jun-2009 |
Publisher: | Nature Research |
Abstract: | Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/27729 |
DOI: | 10.1038/nature08064 |
ISSN: | 0028-0836 |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
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nature08064.pdf | 548.52 kB | Adobe PDF | View/Open |
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