Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/19767
Título: | Synthesis of functionalized benzimidazole-butyrolactone dyads |
Autor: | Bouaziz, Omar Amari, Mohamed Bachar, Rebat Khier, Nawal Fodili, Mokhtar Almeida Paz, Filipe A. Talhi, Oualid Silva, Artur M. S. |
Palavras-chave: | Methylene-gamma-butyrolactones Bridgehead nitrogen atom Heterocyclic-systems Derivatives Acid Thiazolo<3,2-a>Benzimidazol-3(2h)-Ones Inhibitors Pyrazole Chromone Potent |
Data: | 2015 |
Editora: | Elsevier |
Resumo: | A two-step procedure transformation starting from the reaction of ortho-phenylenediamines on 2-acetylbutyrolactone 1 yielded (Z)-3-(1-aminoethylidene)butyrolactones 2, which were treated with either N,N-dimethylformamide dimethyl acetal, triphosgene, or carbon disulfide under different reaction conditions to produce a new series of benzimidazole-, benzimidazolone-, or benzimidazole-2-thione-butyrolactone dyads 3-5, respectively. The structures of compounds 2-5 were established by NMR and mass spectrometry. The isolation of important reaction intermediates as single-crystals allowed the determination of the (Z)-configuration in the resulting conjugate heterocyclic systems 3-5 by X-ray diffraction studies. (C) 2015 Elsevier Ltd. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19767 |
DOI: | 10.1016/j.tetlet.2015.01.039 |
ISSN: | 0040-4039 |
Versão do Editor: | 10.1016/j.tetlet.2015.01.039 |
Aparece nas coleções: | CICECO - Artigos DQ - Artigos QOPNA - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Synthesis of functionalized benzimidazole-butyrolactone dyads_10.1016j.tetlet.2015.01.039.pdf | 443.56 kB | Adobe PDF |
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