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http://hdl.handle.net/10773/18209
Title: | Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines |
Author: | Resende, Diana I. S. P. Guieu, Samuel Oliva, Cristina G. Silva, Artur M. S. |
Keywords: | Pyrrolines Reductive cyclization Michael addition Sstereoselectivity |
Issue Date: | 2015 |
Publisher: | Thieme Publishing |
Abstract: | A general and efficient asymmetric synthesis of Δ1-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5- diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The Δ1-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%). |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/18209 |
DOI: | 10.1055/s-0034-1380144 |
ISSN: | 1437-2096 |
Appears in Collections: | CICECO - Artigos QOPNA - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines_10.1055s-0034-1380144.pdf | 378.68 kB | Adobe PDF | View/Open |
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