Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/11250
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira, M. | pt |
dc.contributor.author | Ahmad, I. | pt |
dc.contributor.author | Maria, V. L. | pt |
dc.contributor.author | Ferreira, C. S. S. | pt |
dc.contributor.author | Serafim, A. | pt |
dc.contributor.author | Bebianno, M. J. | pt |
dc.contributor.author | Pacheco, M. | pt |
dc.contributor.author | Santos, M. A. | pt |
dc.date.accessioned | 2013-10-16T14:52:06Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1383-5718 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/11250 | - |
dc.description.abstract | Genetic lesions (8-hydroxy-2′-deoxyguanosine (8-OHdG) and erythrocytic nuclear abnormalities (ENA) were seasonally quantified in the blood of Liza aurata caught at Ria de Aveiro (Portugal), a multi-contaminated aquatic system. Thus, five critical sites were assessed and compared with a reference site (Torreira). Oxidative DNA damage was found in Gafanha (harbour-water area), Laranjo (metal-contaminated) and Vagos (contaminated with PAHs) in the spring; Rio Novo do Principe (near a former paper-mill effluent) in the autumn; Rio Novo do Principe and Vagos in the winter. ENA were higher than Torreira at VAG (spring and winter). Torreira did not display seasonal variation neither in terms of 8-OHdG or total ENA. A positive correlation between 8-OHdG and ENA was found, suggesting oxidative stress as a mechanism involved in the formation of ENA. This study clearly demonstrates the presence of DNA-damaging substances in Ria de Aveiro and recommends the use of 8-OHdG and ENA as biomarkers of environmental contamination. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | FCT - POCI/MAR/61195/2004 | pt |
dc.relation | FCT - SFRH/BD/27584/2006 | pt |
dc.relation | FCT - SFRH/BPD/26970/2006 | pt |
dc.relation | FCT - SFRH/BPD/34326/2006 | pt |
dc.rights | restrictedAccess | por |
dc.subject | Liza aurata | pt |
dc.subject | Genotoxicity | pt |
dc.subject | 8-Hydroxy-2′-deoxyguanosine | pt |
dc.subject | Erythrocytic nuclear abnormalities | pt |
dc.title | Evaluation of oxidative DNA lesions in plasma and nuclear abnormalities in erythrocytes of wild fish (Liza aurata) as an integrated approach to genotoxicity assessment | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
ua.event.title | Mutation Research-Genetic Toxicology and Environmental Mutagenesis | |
degois.publication.firstPage | 83 | pt |
degois.publication.issue | 2 | pt |
degois.publication.lastPage | 89 | pt |
degois.publication.title | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | pt |
degois.publication.volume | 703 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.doi | 10.1016/j.mrgentox.2010.08.003 | pt |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Evaluation of oxidative DNA lesions in plasma.pdf | 378.57 kB | Adobe PDF |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.