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Title: Biofunctionalized magnetic hydrogel nanospheres of magnetite and k-carrageenan
Author: Daniel-da-Silva, Ana L
Fateixa, Sara
Guiomar, António J
Costa, Benilde F O
Silva, Nuno J O
Trindade, Tito
Goodfellow, Brian J
Gil, Ana M
Issue Date: 2009
Publisher: Institute of Physics
Abstract: Magnetic hydrogel κ-carrageenan nanospheres were successfully prepared via water-in-oil (w/o) microemulsions combined with thermally induced gelation of the polysaccharide. The size of the nanospheres (an average diameter ( ) of about 50 and 75 nm) was modulated by varying the concentration of surfactant. The nanospheres contained superparamagnetic magnetite nanoparticles ( 8 nm), previously prepared by co-precipitation within the biopolymer. Carboxyl groups, at a concentration of about 4 mmol g−1, were successfully grafted at the surface of these magnetic nanospheres via carboxymethylation of the κ-carrageenan. The carboxylated nanospheres were shown to be thermo-sensitive in the 37–45 ◦C temperature range, indicating their potential as thermally controlled delivery systems for drugs and/or magnetic particles at physiological temperatures. Finally, preliminary results have been obtained for IgG antibody conjugation of the carboxylated nanospheres and the potential of these systems for bio-applications is discussed.
Peer review: yes
DOI: 10.1088/0957-4484/20/35/355602
ISSN: 1361-6528
Appears in Collections:DQ - Artigos

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