Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/5136
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dc.contributor.authorTrovatti, Elianept
dc.contributor.authorSilva, Nuno H. C. S.pt
dc.contributor.authorDuarte, Iola F.pt
dc.contributor.authorRosado, Catarina F.pt
dc.contributor.authorAlmeida, Isabel F.pt
dc.contributor.authorCosta, Paulopt
dc.contributor.authorFreire, Carmen S. R.pt
dc.contributor.authorSilvestre, Armando J. D.pt
dc.contributor.authorNeto, Carlos Pascoalpt
dc.date.accessioned2012-01-16T15:55:49Z-
dc.date.issued2011-
dc.identifier.issn1525-7797pt
dc.identifier.urihttp://hdl.handle.net/10773/5136-
dc.description.abstractBiocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.pt
dc.description.sponsorshipFCTpt
dc.description.sponsorshipPOPH/FSEpt
dc.description.sponsorshipSFRH/BPD/63250/2009pt
dc.language.isoengpt
dc.publisherAmerican Chemical Societypt
dc.rightsrestrictedAccesspor
dc.titleBiocellulose Membranes as Supports for Dermal Release of Lidocainept
dc.typearticlept
dc.peerreviewedyespt
ua.distributioninternationalpt
degois.publication.firstPage4162pt
degois.publication.issue11pt
degois.publication.issue11
degois.publication.lastPage4168pt
degois.publication.titleBiomacromoleculespt
degois.publication.volume12pt
dc.date.embargo10000-01-01-
dc.identifier.doi10.1021/bm201303r*
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