Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/42007
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dc.contributor.authorZargarzadeh, Mehrzadpt_PT
dc.contributor.authorGomes, Maria C.pt_PT
dc.contributor.authorPatrício, Sónia G.pt_PT
dc.contributor.authorCustódio, Catarina A.pt_PT
dc.contributor.authorMano, João F.pt_PT
dc.date.accessioned2024-06-11T11:08:09Z-
dc.date.available2024-06-11T11:08:09Z-
dc.date.issued2023-11-23-
dc.identifier.issn1616-301Xpt_PT
dc.identifier.urihttp://hdl.handle.net/10773/42007-
dc.description.abstractPhoto-crosslinkable platelet lysate (PL)-based hydrogels have been proven to support human-derived cell cultures owing to their high content of bioactive molecules, such as cytokines and growth factors. As a unique self-maintained and biocompatible 3D scaffold, the recently reported self-feeding hydrogels with enzyme-empowered degradation capacity have shown high biological performance in vitro and in vivo. To take advantage of all features of both PL and self-feeding hydrogels, here UV responsive laminaran-methacrylate (LamMA) and PL-methacrylate (PLMA) derivatives plus glucoamylase (GA), which significantly improve the overall features of a 3D system, is coupled. This self-sustaining hybrid hydrogel emerges as a unique scaffold due to the sustained delivery of glucose produced via enzymatic degradation of laminaran while granting the release of growth factors through the presence of PL. This biomaterial is applied to fabricate high-throughput freestanding microgels with controlled geometric shapes. Furthermore, this multicomponent hybrid hydrogel is successfully implemented as the first reported glucose supplier bioink to manufacture intricate and precisely defined cell-laden structures using a support matrix. Finally, such hydrogels are utilized as a proof of concept to serve as 3D in vitro cancer models, with the aim of recapitulating the tumor microenvironment.pt_PT
dc.language.isoengpt_PT
dc.publisherWileypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0006%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/883370/EUpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F30869%2F2017/PTpt_PT
dc.relationPOCI-01-0145-FEDER-030869pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F143883%2F2019/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.01647.CEECIND%2FCP1589%2FCT0034/PTpt_PT
dc.rightsrestrictedAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject3D cell culturept_PT
dc.subjectHydrogelspt_PT
dc.subjectLaminaranpt_PT
dc.subjectPlatelet-lysatept_PT
dc.subjectSelf-sustainingpt_PT
dc.titleA self‐sustaining hydrogels with autonomous supply of nutrients and bioactive domains for 3D cell culturept_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.issue48pt_PT
degois.publication.titleAdvanced Functional Materialspt_PT
degois.publication.volume33pt_PT
dc.identifier.doi10.1002/adfm.202214372pt_PT
dc.identifier.essn1616-3028pt_PT
dc.identifier.articlenumber2214372pt_PT
Appears in Collections:CICECO - Artigos
DQ - Artigos

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