Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/40475
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dc.contributor.authorCarvalho, João P. F.pt_PT
dc.contributor.authorTeixeira, Maria C.pt_PT
dc.contributor.authorLameirinhas, Nicole S.pt_PT
dc.contributor.authorMatos, Filipe S.pt_PT
dc.contributor.authorLuís, Jorge L.pt_PT
dc.contributor.authorPires, Lilianapt_PT
dc.contributor.authorOliveira, Helenapt_PT
dc.contributor.authorOliveira, Martinhopt_PT
dc.contributor.authorSilvestre, Armando J. D.pt_PT
dc.contributor.authorVilela, Carlapt_PT
dc.contributor.authorFreire, Carmen S. R.pt_PT
dc.date.accessioned2024-02-01T18:19:38Z-
dc.date.available2024-02-01T18:19:38Z-
dc.date.issued2023-08-30-
dc.identifier.issn1944-8244pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/40475-
dc.description.abstract3D bioprinting is a versatile technique that allows the fabrication of living tissue analogs through the layer-by-layer deposition of cell-laden biomaterials, viz. bioinks. In this work, composite alginate hydrogel-based bioinks reinforced with curcumin-loaded particles of cellulose esters (CEpCUR) and laden with human keratinocytes (HaCaT) are developed. The addition of the CEpCUR particles, with sizes of 740 ± 147 nm, improves the rheological properties of the inks, increasing their shear stress and viscosity, while preserving the recovery rate and the mechanical and viscoelastic properties of the resulting fully cross-linked hydrogels. Moreover, the presence of these particles reduces the degradation rate of the hydrogels from 26.3 ± 0.8% (ALG) to 18.7 ± 1.3% (ALG:CEpCUR_10%) after 3 days in the culture medium. The 3D structures printed with the ALG:CEpCUR inks reveal increased printing definition and the ability to release curcumin (with nearly 70% of cumulative release after 24 h in PBS). After being laden with HaCaT cells (1.2 × 106 cells mL-1), the ALG:CEpCUR bioinks can be successfully 3D bioprinted, and the obtained living constructs show good dimensional stability and high cell viabilities at 7 days post-bioprinting (nearly 90%), confirming their great potential for application in fields like wound healing.pt_PT
dc.language.isoengpt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0006%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F31289%2F2017/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT//2020.09018.BD/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140229%2F2018/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00464%2F2017%2FCP1459%2FCT0033/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00263%2F2018%2FCP1559%2FCT0018/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.01571.CEECIND%2FCP1659%2FCT0024/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F04050%2F2017%2FCP1459%2FCT0023/PTpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject3D bioprintingpt_PT
dc.subjectComposite hydrogel bioinkspt_PT
dc.subjectCellulose ester-based particlespt_PT
dc.subjectDrug deliverypt_PT
dc.subjectLiving tissue analogspt_PT
dc.titleHydrogel bioinks of alginate and curcumin-loaded cellulose ester-based particles for the biofabrication of drug-releasing living tissue analogspt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage40898pt_PT
degois.publication.issue34pt_PT
degois.publication.lastPage40912pt_PT
degois.publication.titleACS Applied Materials & Interfacespt_PT
degois.publication.volume15pt_PT
dc.identifier.doi10.1021/acsami.3c07077pt_PT
dc.identifier.essn1944-8252pt_PT
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