Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/40064
Title: Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis
Author: Nascimento-Gonçalves, Elisabete
Seixas, Fernanda
Palmeira, Carlos
Martins, Gabriela
Fonseca, Carolina
Duarte, José Alberto
Faustino-Rocha, Ana I
Colaço, Bruno
Pires, Maria João
Neuparth, Maria João
Moreira-Gonçalves, Daniel
Fardilha, Margarida
Henriques, Magda C.
Patrício, Daniela
Pelech, Steven
Ferreira, Rita
Oliveira, Paula A
Issue Date: 12-May-2023
Publisher: Springer Nature
Abstract: This work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administration of flutamide, N-methyl-N-nitrosourea and testosterone propionate implants. Serum concentrations of C-reactive protein (CRP) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) were not different among groups. Peripheral levels of γδ T cells were higher in Pca exercised group than in the PCa sedentary group (p < 0.05). Exercise training also induced Oestrogen Receptor (ESR1) upregulation and Mitogen-activated Protein Kinase 13 (MAPK13) downregulation, changed the content of the phosphorylated (at Ser-104) form of this receptor (coded by the gene ESR1) and seemed to increase Erα phosphorylation and activity in exercised PCa rats when compared with sedentary PCa rats. Our data highlight the exercise-induced remodelling of peripheral lymphocyte subpopulations and lymphocyte infiltration in prostate tissue. Moreover, exercise training promotes the remodelling prostate signalome in this rat model of prostate carcinogenesis.
Peer review: yes
URI: http://hdl.handle.net/10773/40064
DOI: 10.1007/s11357-023-00806-5
ISSN: 2509-2715
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