Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/39400
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dc.contributor.authorMonteiro, Ana R.pt_PT
dc.contributor.authorRamos, Catarina I. V.pt_PT
dc.contributor.authorFateixa, Sarapt_PT
dc.contributor.authorNeves, Maria G. P. M. S.pt_PT
dc.contributor.authorTrindade, Titopt_PT
dc.date.accessioned2023-09-14T15:15:46Z-
dc.date.issued2023-
dc.identifier.issn1144-0546pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/39400-
dc.description.abstractThe functionalization of deoxyribonucleic acid (DNA) with nanomaterials is a promising strategy to optimize the loading and efficiency of drugs in targeted clinical therapies. Herein we report a novel approach to construct arrays comprising blue- (B) or aqua green- (AG) emitting ethylenediamine-modified graphene quantum dots (GQDs) and DNA oligonucleotides that are able to fold into different structures, namely G-quadruplexes (G4s). The obtained results indicate that GQDs partially modulate the conformation of oligonucleotides, resulting in GQDs-DNA bioconjugates with higher affinity to carry 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP), in comparison to non-modified DNA sequences. TMPyP shows a higher affinity, expressed by a lower dissociation constant (KD), to GQDs-B-G4-1 (0.229 μM) and to GQDs-AG-G4-1 (KD of 0.326 μM) in comparison with non-modified G4-1 (KD of 0.440 μM). The carrier systems with the highest affinity to TMPyP correspond to GQDs-AG with telomeric unimolecular G4 sequence (GQDs-AG-G4-2, KD of 0.111 μM) and GQDs-AG with a non-G4 sequence (GQDs-AG-non-G4, KD of 0.110 μM), followed by their analogues with GQDs-B. While uncovering terra incognita, it is anticipated that GQDs-DNA arrays may be potential photoluminescent nanovehicles to carry other cationic anticancer drugs and allow more targeted therapies.pt_PT
dc.language.isoengpt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PTpt_PT
dc.relationLA/P/0006/2020pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F137356%2F2018/PTpt_PT
dc.relationREF.-069-88-ARH/2018pt_PT
dc.relationREF.-047-88-ARH/2018pt_PT
dc.rightsembargoedAccesspor
dc.titleArrays of graphene-quantum dots-supported DNA oligonucleotides as self-indicating porphyrin carrierspt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.titleNew Journal of Chemistrypt_PT
dc.date.embargo2024-08-09-
dc.identifier.doi10.1039/D3NJ03280Apt_PT
dc.identifier.essn1369-9261pt_PT
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