Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/37953
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dc.contributor.authorValečka, Janpt_PT
dc.contributor.authorCamosseto, Voahiranapt_PT
dc.contributor.authorMcEwan, David G.pt_PT
dc.contributor.authorTerawaki, Seigopt_PT
dc.contributor.authorLiu, Zhuangzhuangpt_PT
dc.contributor.authorStrock, Evapt_PT
dc.contributor.authorAlmeida, Catarina R.pt_PT
dc.contributor.authorSu, Bingpt_PT
dc.contributor.authorDikic, Ivanpt_PT
dc.contributor.authorLiang, Yinmingpt_PT
dc.contributor.authorGatti, Evelinapt_PT
dc.contributor.authorPierre, Philippept_PT
dc.date.accessioned2023-06-07T13:28:21Z-
dc.date.available2023-06-07T13:28:21Z-
dc.date.issued2021-07-
dc.identifier.urihttp://hdl.handle.net/10773/37953-
dc.description.abstractWe report here that RUFY4, a newly characterized member of the 'RUN and FYVE domain-containing' family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that rufy4 messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes.pt_PT
dc.language.isoengpt_PT
dc.publisherThe Royal Societypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-CEL%2F28791%2F2017/PTpt_PT
dc.relationPOCI-01-0145-FEDER-028791pt_PT
dc.relationPOCI-01-0145-FEDER-030882pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-MOL%2F30882%2F2017/PTpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRUFYpt_PT
dc.subjectMitophagypt_PT
dc.subjectSkppt_PT
dc.subjectAlveolar macrophagespt_PT
dc.subjectLPSpt_PT
dc.titleRUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophagespt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.issue7pt_PT
degois.publication.titleRoyal Society Open Sciencept_PT
degois.publication.volume8pt_PT
dc.identifier.doi10.1098/rsos.202333pt_PT
dc.identifier.essn2054-5703pt_PT
dc.identifier.articlenumber202333pt_PT
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