Please use this identifier to cite or link to this item:
Title: Frailty syndrome, biomarkers and environmental factors - a pilot study
Author: Teixeira-Gomes, Armanda
Lage, Bruna
Esteves, Filipa
Sousa, Ana Catarina
Pastorinho, M. Ramiro
Valdiglesias, Vanessa
Costa, Solange
Laffon, Blanca
Teixeira, João Paulo
Keywords: Frailty
DNA damage
H2AX phosphorylation
Exposure history
Issue Date: 15-Sep-2020
Publisher: Elsevier
Abstract: Frailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The study population was classified as 45.1% robust, 45.1% pre-frail and 9.8% frail. A significant higher prevalence of second-hand smokers was found in the pre-frail group when compared to robust. Furthermore, a higher prevalence of robust individuals was found among those consuming home-produced vegetables and water from well/springs. Significant differences were found between data collected in a lifetime exposure questionnaire (LTEQ) and the levels of genotoxicity endpoints and the mercury levels analysed regarding some exposure-related parameters, namely, smoking habits, intake of home-produced vegetables and the use of pesticides in agriculture. Understanding if the way we live(d) or worked can impact the way we age are important questions to be explored. Data obtained in this pilot study encourage further studies on this matter, exploring the role of exposures history and its impact on health.
Peer review: yes
DOI: 10.1016/j.toxlet.2020.04.023
ISSN: 0378-4274
Appears in Collections:CICECO - Artigos
DQ - Artigos

Files in This Item:
File Description SizeFormat 
Frailty syndrome, biomarkers and environmental factors (2).pdf2.51 MBAdobe PDFView/Open

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.