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http://hdl.handle.net/10773/36535
Título: | Osseointegration assessment of multi‐material Ti6Al4V‐β TCP implants: an experimental study in rats |
Autor: | Costa, Mafalda M. Miranda, Alice Bartolomeu, Flávio Carvalho, Óscar Matos, Sérgio Silva, Filipe Samuel Miranda, Georgina |
Palavras-chave: | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-βTCP |
Data: | 2022 |
Editora: | Wiley |
Resumo: | In the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/36535 |
DOI: | 10.1002/admt.202101117 |
Aparece nas coleções: | CICECO - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Osseointegration Assessment of Multi-Material Ti6Al4V-βTCP Implants - An Experimental Study in Rats.pdf | 3.81 MB | Adobe PDF |
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