Please use this identifier to cite or link to this item:
Title: Osseointegration assessment of multi‐material Ti6Al4V‐β TCP implants: an experimental study in rats
Author: Costa, Mafalda M.
Miranda, Alice
Bartolomeu, Flávio
Carvalho, Óscar
Matos, Sérgio
Silva, Filipe Samuel
Miranda, Georgina
Keywords: In vivo
Laser surface texturing
Issue Date: 2022
Publisher: Wiley
Abstract: In the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants.
Peer review: yes
DOI: 10.1002/admt.202101117
Appears in Collections:CICECO - Artigos

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.