Please use this identifier to cite or link to this item:
Title: Dissolvable Carboxymethylcellulose Microneedles for Noninvasive and Rapid Administration of Diclofenac Sodium
Author: Silva, Ana C. Q.
Pereira, Bárbara
Lameirinhas, Nicole S.
Costa, P. C.
Almeida, I. F.
Dias-Pereira, P.
Correia-Sá, I.
Oliveira, Helena
Silvestre, Armando J. D.
Vilela, Carla
Freire, Carmen S. R.
Issue Date: 2022
Publisher: Wiley-Blackwell
Abstract: The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC), a water-soluble cellulose derivative with good film-forming ability, by micromolding technology for the transdermal delivery of diclofenac sodium salt (DCF). The MNs with ≈456 µm in height displayed adequate morphology, thermal stability up to 200 °C, and the required mechanical strength for skin insertion (>0.15 N needle−1). Experiments in ex vivo abdominal human skin demonstrate the insertion capability of the CMC_DCF MNs up to 401 µm in depth. The dissolution of the patches in saline buffer results in a maximum cumulative release of 98% of diclofenac after 40 min, and insertion in a skin simulant reveals that all MNs completely dissolve within 10 min. Moreover, the MN patches are noncytotoxic toward human keratinocytes. These results suggest that the MN patches produced with CMC are promising biopolymeric systems for the rapid administration of DCF in a minimally invasive manner.
Peer review: yes
DOI: 10.1002/mabi.202200323
ISSN: 1616-5187
Appears in Collections:CESAM - Artigos
CICECO - Artigos

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.