Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/36058
Title: | Boosting antibiotics performance by new formulations with deep eutectic solvents |
Author: | Pedro, Sónia N. Gomes, Ana T. P. C. Oskoei, Párástu Oliveira, Helena Almeida, Adelaide Freire, Mara G. Silvestre, Armando J. D. Freire, Carmen S. R. |
Keywords: | Ciprofloxacin Humans Microbial Sensitivity Tests Solvents Staphylococcus aureus Anti-Bacterial Agents Deep Eutectic Solvents |
Issue Date: | 25-Mar-2022 |
Publisher: | Elsevier |
Abstract: | The critical scenario of antimicrobial resistance to antibiotics highlights the need for improved therapeutics and/or formulations. Herein, we demonstrate that deep eutectic solvents (DES) formulations are very promising to remarkably improve the solubility, stability and therapeutic efficacy of antibiotics, such as ciprofloxacin. DES aqueous solutions enhance the solubility of ciprofloxacin up to 430-fold while extending the antibiotic stability. The developed formulations can improve, by 2 to 4-fold, the susceptibility of Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria to the antibiotic. They also improve the therapeutic efficacy at concentrations where bacteria present resistance, without promoting tolerance development to ciprofloxacin. Furthermore, the incorporation of DES decreases the toxicity of ciprofloxacin towards immortalized human epidermal keratinocytes (HaCat cells). The results herein reveal the pioneering use of DES in fluoroquinolone-based formulations and their impact on the antibiotic's characteristics and on its therapeutic action. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/36058 |
DOI: | 10.1016/j.ijpharm.2022.121566 |
ISSN: | 0378-5173 |
Appears in Collections: | CESAM - Artigos CICECO - Artigos DBio - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S037851732200120X-main.pdf | 2.91 MB | Adobe PDF | View/Open |
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