Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/35848
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMenilli, Lucapt_PT
dc.contributor.authorMonteiro, Ana Ritapt_PT
dc.contributor.authorLazzarotto, Silviapt_PT
dc.contributor.authorMorais, Filipe M. P.pt_PT
dc.contributor.authorGomes, Ana T. P. C.pt_PT
dc.contributor.authorMoura, Nuno M. M.pt_PT
dc.contributor.authorFateixa, Sarapt_PT
dc.contributor.authorFaustino, Maria A. F.pt_PT
dc.contributor.authorNeves, Maria G. P. M. S.pt_PT
dc.contributor.authorTrindade, Titopt_PT
dc.contributor.authorMiolo, Giorgiapt_PT
dc.date.accessioned2023-01-18T12:32:48Z-
dc.date.available2023-01-18T12:32:48Z-
dc.date.issued2021-09-18-
dc.identifier.issn1999-4923pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/35848-
dc.description.abstractThe development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is of utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, and P1-C5) were non-covalently loaded onto graphene oxide (GO) or graphene quantum dots (GQDs) in a one-step process. The cytotoxic effects of the free PS and of the corresponding hybrids were compared upon blue (BL) and red-light (RL) exposure on T24 human BC cells. In addition, intracellular reactive oxygen species (ROS) and singlet oxygen generation were measured. TMPyP and Zn-TMPyP showed higher efficiency under BL (IC50: 0.42 and 0.22 μm, respectively), while P1-C5 was more active under RL (IC50: 0.14 μm). In general, these PS could induce apoptotic cell death through lysosomes damage. The in vitro photosensitizing activity of the PS was not compromised after their immobilization onto graphene-based nanomaterials, with Zn-TMPyP@GQDs being the most promising hybrid system under RL (IC50: 0.37 μg/mL). Overall, our data confirm that GO and GQDs may represent valid platforms for PS delivery, without altering their performance for PDT on BC cells.pt_PT
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationCPDA150854pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTpt_PT
dc.relationUID/CTM/50011/2020pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F137356%2F2018/PTpt_PT
dc.relationREF.-048-88-ARH/2018pt_PT
dc.relationREF.-069-88-ARH/2018pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleGraphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cellspt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.issue9pt_PT
degois.publication.titlePharmaceuticspt_PT
degois.publication.volume13pt_PT
dc.identifier.doi10.3390/pharmaceutics13091512pt_PT
dc.identifier.articlenumber1512pt_PT
Appears in Collections:CESAM - Artigos
CICECO - Artigos
REQUIMTE - Artigos



FacebookTwitterLinkedIn
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.