Please use this identifier to cite or link to this item:
|Title:||Hybrids based on graphene oxide and porphyrin as tools for detection and stabilization of DNA G-Quadruplexes|
|Author:||Monteiro, Ana R.|
Ramos, Catarina I. V.
Moura, Nuno M. M.
Neves, Maria G. P. M. S.
|Publisher:||American Chemical Society|
|Abstract:||Telomerase inhibition has been an important strategy in cancer therapies, but for which effective drugs are still required. Here, noncovalent hybrid nanoplatforms containing the tetracationic 5,10,15,20-tetrakis(1-methyl-pyridinium-4-yl)porphyrin (TMPyP) and graphene oxide (GO) were prepared for promoting telomerase inhibition through the selective detection and stabilization of DNA guanine-quadruplex (G-Q) structures. Upon binding TMPyP to the GO sheets, the typical absorption bands of porphyrin have been red-shifted and the fluorescence emission was quenched. Raman mapping was used for the first time to provide new insights into the role of the electrostatic and π-π stacking interactions in the formation of such hybrids. The selective recovery of fluorescence observed during the titration of TMPyP@GO with G-Q, resembles a selective "turn-off-on" fluorescence sensor for the detection of G-Q, paving the way for a new class of antitumor drugs.|
|Appears in Collections:||CICECO - Artigos|
Files in This Item:
|Hybrids Based on Graphene Oxide and Porphyrin as Tools for Detection and Stabilization of DNA G‐Quadruplexes.pdf||4.87 MB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.