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Title: Hybrids based on graphene oxide and porphyrin as tools for detection and stabilization of DNA G-Quadruplexes
Author: Monteiro, Ana R.
Ramos, Catarina I. V.
Fateixa, Sara
Moura, Nuno M. M.
Neves, Maria G. P. M. S.
Trindade, Tito
Issue Date: 30-Sep-2018
Publisher: American Chemical Society
Abstract: Telomerase inhibition has been an important strategy in cancer therapies, but for which effective drugs are still required. Here, noncovalent hybrid nanoplatforms containing the tetracationic 5,10,15,20-tetrakis(1-methyl-pyridinium-4-yl)porphyrin (TMPyP) and graphene oxide (GO) were prepared for promoting telomerase inhibition through the selective detection and stabilization of DNA guanine-quadruplex (G-Q) structures. Upon binding TMPyP to the GO sheets, the typical absorption bands of porphyrin have been red-shifted and the fluorescence emission was quenched. Raman mapping was used for the first time to provide new insights into the role of the electrostatic and π-π stacking interactions in the formation of such hybrids. The selective recovery of fluorescence observed during the titration of TMPyP@GO with G-Q, resembles a selective "turn-off-on" fluorescence sensor for the detection of G-Q, paving the way for a new class of antitumor drugs.
Peer review: yes
DOI: 10.1021/acsomega.8b01366
Appears in Collections:CICECO - Artigos

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