Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/35552
Title: Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
Author: Bharmoria, Pankaj
Bisht, Meena
Gomes, Maria C.
Martins, Margarida
Neves, Márcia C.
Mano, João F.
Bdikin, Igor
Coutinho, João A. P.
Ventura, Sónia P. M.
Keywords: Animals
Antineoplastic agents
Breast neoplasms
Cell line
Curcumin
Drug carriers
Drug delivery systems
Drug stability
Emulsions
Female
Fibroblasts
Gelatin
Humans
Mice
Nanostructures
Olive Oil
Poloxamer
Water
Phytogenic
Tumor
Issue Date: 27-Apr-2021
Publisher: Nature Research
Abstract: The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept.
Peer review: yes
URI: http://hdl.handle.net/10773/35552
DOI: 10.1038/s41598-021-88482-3
Appears in Collections:CICECO - Artigos

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