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http://hdl.handle.net/10773/35552
Title: | Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells |
Author: | Bharmoria, Pankaj Bisht, Meena Gomes, Maria C. Martins, Margarida Neves, Márcia C. Mano, João F. Bdikin, Igor Coutinho, João A. P. Ventura, Sónia P. M. |
Keywords: | Animals Antineoplastic agents Breast neoplasms Cell line Curcumin Drug carriers Drug delivery systems Drug stability Emulsions Female Fibroblasts Gelatin Humans Mice Nanostructures Olive Oil Poloxamer Water Phytogenic Tumor |
Issue Date: | 27-Apr-2021 |
Publisher: | Nature Research |
Abstract: | The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/35552 |
DOI: | 10.1038/s41598-021-88482-3 |
Appears in Collections: | CICECO - Artigos |
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