Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/35171
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dc.contributor.authorRocha, Vâniapt_PT
dc.contributor.authorPaixão, Cátiapt_PT
dc.contributor.authorMarques, Aldapt_PT
dc.date.accessioned2022-11-11T14:58:21Z-
dc.date.available2022-11-11T14:58:21Z-
dc.date.issued2022-
dc.identifier.issn1440-2440pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/35171-
dc.description.abstractObjectives Physical activity and exercise measures show potential to predict mortality in people with interstitial lung disease. This study summarized evidence on the association between physical activity and exercise capacity measures and mortality risk in people with interstitial lung disease and quantified its magnitude by meta-analysis. Design Systematic review and meta-analysis. Methods PubMed, Scopus, Web of Science and EBSCO were searched until May 2020 with updates until September 2021. Two authors screened studies, extracted data, and assessed risk of bias. A random-effects meta-analysis for each physical activity measure was conducted using logarithmic hazard ratios. Results Fifty-two studies of 10,349-people with interstitial lung disease (64 ± 9 years; 67%men) were included. A significant association between at least one measure of physical activity and exercise and mortality risk was found in 44-studies. Most reported measures were the six-minute walk test, oxygen uptake (VO2), work (watts-W) and time spent in physical activity. Meta-analysis showed that individuals with six-minute walk distance < 250 m had more than twofold higher mortality risk, than those with six-minute walk distance ≥ 350 m. Individuals presenting a six-minute walk distance decrease ≥ 26 m over 6–48 months showed an almost threefold higher mortality risk. An increase of 10–20 W or 10 %predicted in workload and a time spent in physical activity ≥ 100 min/week or ≥0.031 kcal/min/kg/day were associated with an overall 12 % and 45 % lower mortality risk, respectively. Conclusions Physical activity and exercise capacity measures were associated with mortality risk in people with interstitial lung disease. Most studies used the six-minute walk test and more evidence is needed on the other measures (i.e., VO2, work and physical activity time). Personalized interventions to improve physical activity and exercise capacity should be considered to delay premature mortality in people with interstitial lung disease.pt_PT
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-028806pt_PT
dc.relationPTDC/SAUSER/28806/2017pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04501%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F148741%2F2019/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04501%2F2020/PTpt_PT
dc.rightsopenAccesspt_PT
dc.subjectRespiratory tract diseasespt_PT
dc.subjectPhysical activitypt_PT
dc.subjectExercise capacitypt_PT
dc.subjectReview literaturept_PT
dc.subjectSurvivalpt_PT
dc.titlePhysical activity, exercise capacity and mortality risk in people with interstitial lung disease: a systematic review and meta-analysispt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage903pt_PT
degois.publication.issue11pt_PT
degois.publication.lastPage910pt_PT
degois.publication.titleJournal of Science and Medicine in Sportpt_PT
degois.publication.volume25pt_PT
dc.identifier.doi10.1016/j.jsams.2022.10.002pt_PT
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