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Title: The role of non-standard translation in Candida albicans pathogenesis
Author: Bezerra, Ana Rita
Oliveira, Carla
Correia, Inês
Guimarães, Ana Rita
Sousa, Gonçalo
Carvalho, Maria João
Moura, Gabriela
Santos, Manuel A. S.
Keywords: Candida albicans
Drug resistance
Genetic diversity
Non-standard translation
Issue Date: Jun-2021
Publisher: Oxford University Press
Abstract: Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits.
Peer review: yes
DOI: 10.1093/femsyr/foab032
ISSN: 1567-1356
Appears in Collections:IBIMED - Artigos
DCM - Artigos

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