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Title: tRNAs as a driving force of genome evolution in yeast
Author: Guimarães, Ana Rita
Correia, Inês
Sousa, Inês
Oliveira, Carla
Moura, Gabriela
Bezerra, Ana Rita
Santos, Manuel A.S.
Keywords: tRNA
Chromatin structure
Chromosome architecture
Genome evolution
Genomic instability
Issue Date: Mar-2021
Publisher: Frontiers Media S.A.
Abstract: Transfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation, including sensing amino acid abundance, interacting with the general stress response machinery, and modulating cellular adaptation, survival, and death. In this mini-review, we focus on the emerging role of tRNA genes in the organization and modification of the genomic architecture of yeast and the role of tRNA misexpression and decoding infidelity in genome stability, evolution, and adaption. We discuss published work showing how quickly tRNA genes can mutate to meet novel translational demands, how tRNAs speed up genome evolution, and how tRNA genes can be sites of genomic instability. We highlight recent works showing that loss of tRNA decoding fidelity and small alterations in tRNA expression have unexpected and profound impacts on genome stability. By dissecting these recent evidence, we hope to lay the groundwork that prompts future investigations on the mechanistic interplay between tRNAs and genome modification that likely triggers genome evolution.
Peer review: yes
DOI: 10.3389/fmicb.2021.634004
ISSN: 1664-302X
Appears in Collections:IBIMED - Artigos
DCM - Artigos

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