Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/34621
Title: | Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering |
Author: | Jesus, Diana Pinho, Ana R. Gomes, Maria C. Oliveira, Cláudia S. Mano, João F. |
Keywords: | Bone regeneration Cell differentiation Cues Tissue engineering Osteogenesis Tissue scaffolds |
Issue Date: | 28-Apr-2022 |
Publisher: | Royal Society of Chemistry |
Abstract: | Bone presents an intrinsic ability for self-regeneration and repair, however critical defects and large fractures require invasive and time-consuming clinical interventions. As an alternative to current therapy, bone tissue engineering (BTE) has primarily aimed to recreate the bone microenvironment by delivering key biomolecules and/or by modification of scaffolds to guide cell fate towards the osteogenic lineage or other phenotypes that may benefit the bone regeneration mechanism. Considering that bone cells communicate, in their native microenvironment, through biochemical and physical signals, most strategies fail when considering only chemical, geometrical or mechanical cues. This is not representative of the physiological conditions, where the cells are simultaneously in contact and stimulated by several cues. Therefore, this review explores the synergistic effect of biochemical/physical cues in regulating cellular events, namely cell adhesion, proliferation, osteogenic differentiation, and mineralization, highlighting the importance of the combined modifications for the development of innovative bone regenerative therapies. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/34621 |
DOI: | 10.1039/d2sm00009a |
ISSN: | 1744-683X |
Appears in Collections: | CICECO - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Review ARP DJ VF.pdf | 594.55 kB | Adobe PDF | View/Open |
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