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|IonCytDevice: removal of cytostatics from cancer patients’ urine using supported ionic liquids
|Silva, Francisca A. e
Santos, Maria J.
Neves, Márcia C.
Sousa, Ana C. A.
Freire, Mara G.
|Cancer prevalence is rising at a fast rate, registering 18.1 million new cancer cases in 2018. Aiming to provide better therapeutic options and to boost survivorship and life quality of cancer patients, the medical field contributed to significant progresses. Under this framework, the consumption of anticancer drugs, namely cytostatics, increased over the past years. However, urinary excretion of cystostatic drugs by cancer patients has contributed to an important source of contamination in wastewater treatment plants (WWTPs), and consequently to the aquatic environment. In order to tackle the environmental burden associated to anticancer drugs consumption, the development of point source removal strategies is of high demand. Supported ionic liquids (SILs) can be envisaged as suitable tools for such a purpose, since they join the advantages of solid supports and the tunable characteristics of ILs. In this work, the synthesis and characterization of several SILs using silica as the support material was performed. The SILs adsorption capacity for distinct cytostatic drugs, namely cyclophosphamide (CP) and mycophenoloate mofetil (MMF), was appraised by determining adsorption kinetics and isotherms. By the manipulation of the ILs’ cation structure, improved removal of cystostatics from aqueous samples is attained, enabling the design of high-performance alternative adsorbents, which will be investigated in continuous mode and using urine samples in the future.
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|CICECO - Comunicações
DQ - Comunicações
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|e Silve et al. Workshop (1).pdf
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