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Title: The worldwide covid-19 genetic risk scenario
Author: Marçalo, Rui
Neto, Sonya
Pinheiro, Miguel
Rodrigues, Ana
Sousa, Nuno
Santos, Manuel
Simão, Paula
Valente, Carla
Andrade, Lília
Marques, Alda
Moura, Gabriela
Keywords: COVID-19
Issue Date: 5-Sep-2021
Publisher: European Respiratory Society
Abstract: Populations respond differently to the current global pandemic of covid-19. This study explores the role of individual factors in the differential response to covid-19, by looking at the genetic background of worldwide populations. Significant SNPs (susceptibility: rs286914/rs12329760; severity: rs657152/rs11385942) were selected from the literature and their allelic frequencies used to calculate the probability of having multiple risk alleles in each population. Portuguese (n=623), Spanish (n=9761) and Italian (n=6363) populations data are observed values, whereas data for world populations are estimations based on public information. All populations, even those with European ancestry (Portuguese/Spanish/Italian), were significantly different from the European population in both covid-19 susceptibility and severity (all p-values < 0.0001)(Fig. 1). Our study highlights a genetic heterogeneity across world populations, especially within European subpopulations. There is a need to build a European genetic map so that differences in the distribution of relevant alleles can be easily accessed and used to better manage the populations, ultimately, safeguarding those under higher genetic risk.
Peer review: yes
DOI: 10.1183/13993003.congress-2021.PA675
ISSN: 0903-1936
Appears in Collections:ESSUA - Comunicações
DCM - Comunicações
IBIMED - Comunicações
Lab3R - Comunicações

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