Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/33667
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dc.contributor.authorMarçalo, Ruipt_PT
dc.contributor.authorNeto, Sonyapt_PT
dc.contributor.authorPinheiro, Miguelpt_PT
dc.contributor.authorRodrigues, Anapt_PT
dc.contributor.authorSousa, Nunopt_PT
dc.contributor.authorSantos, Manuelpt_PT
dc.contributor.authorSimão, Paulapt_PT
dc.contributor.authorValente, Carlapt_PT
dc.contributor.authorAndrade, Líliapt_PT
dc.contributor.authorMarques, Aldapt_PT
dc.contributor.authorMoura, Gabrielapt_PT
dc.date.accessioned2022-04-11T18:01:04Z-
dc.date.available2022-04-11T18:01:04Z-
dc.date.issued2021-09-05-
dc.identifier.issn0903-1936-
dc.identifier.urihttp://hdl.handle.net/10773/33667-
dc.description.abstractPopulations respond differently to the current global pandemic of covid-19. This study explores the role of individual factors in the differential response to covid-19, by looking at the genetic background of worldwide populations. Significant SNPs (susceptibility: rs286914/rs12329760; severity: rs657152/rs11385942) were selected from the literature and their allelic frequencies used to calculate the probability of having multiple risk alleles in each population. Portuguese (n=623), Spanish (n=9761) and Italian (n=6363) populations data are observed values, whereas data for world populations are estimations based on public information. All populations, even those with European ancestry (Portuguese/Spanish/Italian), were significantly different from the European population in both covid-19 susceptibility and severity (all p-values < 0.0001)(Fig. 1). Our study highlights a genetic heterogeneity across world populations, especially within European subpopulations. There is a need to build a European genetic map so that differences in the distribution of relevant alleles can be easily accessed and used to better manage the populations, ultimately, safeguarding those under higher genetic risk.pt_PT
dc.language.isoengpt_PT
dc.publisherEuropean Respiratory Societypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-PIC%2F2284%2F2014/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-MIC%2F31849%2F2017/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04501%2F2020/PTpt_PT
dc.relationPOCI-01-0145-FEDER-028806pt_PT
dc.relationCENTRO-01-0246-FEDER-000018pt_PT
dc.relationCENTRO-08-5864-FSE-000039pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/UI%2FBD%2F151337%2F2021/PTpt_PT
dc.rightsopenAccesspt_PT
dc.subjectCOVID-19pt_PT
dc.subjectGeneticpt_PT
dc.subjectPopulationspt_PT
dc.titleThe worldwide covid-19 genetic risk scenariopt_PT
dc.typeconferenceObjectpt_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
ua.event.date4-8 September, 2021pt_PT
degois.publication.issuesuppl 65pt_PT
degois.publication.titleEuropean Respiratory Journalpt_PT
degois.publication.volume58pt_PT
dc.identifier.doi10.1183/13993003.congress-2021.PA675pt_PT
dc.identifier.essn1399-3003-
dc.identifier.articlenumberPA675pt_PT
Appears in Collections:ESSUA - Comunicações
DCM - Comunicações
IBIMED - Comunicações
Lab3R - Comunicações

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