Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/33197
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dc.contributor.authorCarreira, Ana R. F.pt_PT
dc.contributor.authorVeloso, Telmapt_PT
dc.contributor.authorSchaeffer, Nicolaspt_PT
dc.contributor.authorPereira, Joana L.pt_PT
dc.contributor.authorVentura, Sónia P. M.pt_PT
dc.contributor.authorRizzi, Cécilept_PT
dc.contributor.authorPlénet, Juliette Sirieixpt_PT
dc.contributor.authorPassos, Helenapt_PT
dc.contributor.authorCoutinho, João A. P.pt_PT
dc.date.accessioned2022-02-15T19:40:19Z-
dc.date.available2022-02-15T19:40:19Z-
dc.date.issued2021-11-02-
dc.identifier.urihttp://hdl.handle.net/10773/33197-
dc.description.abstractBio-based ionic liquids (ILs) are being increasingly sought after, as they are more sustainable and eco-friendly. Purines are the most widely distributed, naturally occurring N-heterocycles, but their low water-solubility limits their application. In this work, four purines (theobromine, theophylline, xanthine, and uric acid) were combined with the cation tetrabutylammonium to synthesize bio-based ILs. The physico-chemical properties of the purine-based ILs were characterized, including their melting and decomposition temperatures and water-solubility. The ecotoxicity against the microalgae Raphidocelis subcapitata was also determined. The ILs show good thermal stability (>457 K) and an aqueous solubility enhancement ranging from 53- to 870-fold, in comparison to their respective purine percursors, unlocking new prospects for their application where aqueous solutions are demanded. The ecotoxicity of these ILs seems to be dominated by the cation, and it is similar to chloride-based IL, emphasizing that the use of natural anions does not necessarily translate to more benign ILs. The application of the novel ILs in the formation of aqueous biphasic systems (ABS), and as solubility enhancers, was also evaluated. The ILs were able to form ABS with sodium sulfate and tripotassium citrate salts. The development of thermoresponsive ABS, using sodium sulfate as a salting-out agent, was accomplished, with the ILs having different thermosensitivities. In addition, the purine-based ILs acted as solubility enhancers of ferulic acid in aqueous solution.pt_PT
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationUIDB/50011/2020pt_PT
dc.relationUIDP/50011/2020pt_PT
dc.relationUIDP/50017/2020pt_PT
dc.relationUIDB/50017/2020pt_PT
dc.relationSFRH/BD/143612/2019pt_PT
dc.relationSFRH/BD/147346/2019pt_PT
dc.relationCEECIND/00831/2017pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSynthesispt_PT
dc.subjectEcotoxicitypt_PT
dc.subjectSolubilitypt_PT
dc.subjectLiquid–liquid equilibriumpt_PT
dc.subjectThermoresponsive systemspt_PT
dc.titleSynthesis of purine-based ionic liquids and their applicationspt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.issue22pt_PT
degois.publication.titleMoleculespt_PT
degois.publication.volume26pt_PT
dc.identifier.doi10.3390/molecules26226958pt_PT
dc.identifier.essn1420-3049pt_PT
dc.identifier.articlenumber6958pt_PT
Appears in Collections:CESAM - Artigos
CICECO - Artigos
DBio - Artigos
DQ - Artigos

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