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Title: A selective journey: enantioselective biphasic systems for the resolution of propranolol
Author: Carreira, Ana R. F.
Ferreira, Ana M.
Almeida, Mafalda R.
Coutinho, João A. P.
Sintra, Tânia E.
Keywords: Enantioseparation
Esters of tartaric acid
Chiral ionic liquids
Aqueous biphasic systems
Enantioselective liquid–liquid extraction
Issue Date: Nov-2020
Abstract: Enantiomers may have different biological properties, leading to complications when using racemates for the treatment of diseases. Considering the difficulty in the synthesis of pure enantiomers, the synthesis of racemates followed by their chiral resolution is deemed as a simpler and cheaper alternative. Enantioselective liquid-liquid extraction (ELLE) is a promising separation process. ELLE is composed of two immiscible phases that enable the optimization of enantioseparation through the addition of a chiral selector, such as chiral ionic liquids (CIL) or tartaric acid derivatives. Upon their introduction in ELLE, these chiral selectors may help increase the selectivity of the system, contributing to high performant extraction/separation approaches. In this work, CILs and tartaric acid derivatives were used in biphasic systems as chiral selectors, aiming to separate R/S-propranolol (R/S-PRP) enantiomers. The most promising system was applied in centrifugal partition chromatography to further improve the enantiomeric purification rates.
Peer review: yes
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Appears in Collections:CICECO - Comunicações
DQ - Comunicações

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