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Title: Automated fabrication of 3D chondrocyte-laden anisotropic scaffolds for articular cartilage
Author: Semitela, Â.
Pereira, A. L.
Capitão, A.
Mendes, A. F.
Marques, P. A. A. P.
Completo, A.
Issue Date: 11-Nov-2021
Publisher: Taylor & Francis
Abstract: Tissue engineering (TE) strategies for repairing and regenerating articular car-tilage face critical challenges to approximate the biochemical and biomechanical microen-vironment of native tissue, particularly regarding collagen fibril depth-orientation and chondrocyte distribution. Here, a recently developed electromechanically 3D electrospin-ning platform was employed to develop three-dimensional (3D) anisotropic electrospun scaffolds in a fully automated manner with simultaneous chondrocyte incorporation. As expected, the 3D scaffolds possessed an arcade-like fibrous configuration with a uniform chondrocyte distribution. Overall, the results suggest that this combined approach has potential for cartilage TE.
Peer review: yes
DOI: 10.1201/9781003217152-42
Appears in Collections:TEMA - Capítulo de livro
DEM - Capítulo de livro

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