Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/32702
Title: | Brewer's yeast polysaccharides: a review of their exquisite structural features and biomedical applications |
Author: | Bastos, Rita Oliveira, Patrícia G. Gaspar, Vítor M. Mano, João F. Coimbra, Manuel A. Coelho, Elisabete |
Keywords: | Brewer’s spent yeast Beta-glucan Mannoprotein Microcapsule Regenerative medicine Drug delivery |
Issue Date: | 1-Feb-2022 |
Publisher: | Elsevier |
Abstract: | Recent advances on brewer’s yeast cell wall polysaccharides have unraveled exquisite structural features and diverse composition with (β1→3), (β1→6), (α1→4), (β1→4)- mix-linked glucans that are recognized to interact with different cell receptors and trigger specific biological responses. Herein, a comprehensive showcase of structurebiofunctional relationships between yeast polysaccharides and their biological targets is highlighted, with a focus on polysaccharide features that govern the biomedical activity. The insolubility of β-glucans is a crucial factor for binding and activation of Dectin-1 receptor, operating as adjuvants of immune responses. Contrarily, soluble low molecular weight β-glucans have a strong inhibition of reactive oxygen species production, acting as antagonists of Dectin-1 mediated signaling. Soluble glucan-protein moieties can also act as antitumoral agents. The balance between mannoproteins-TLR2 and β-glucans-Dectin-1 receptors-activation is crucial for osteogenesis. Biomedical applications value can also be obtained from yeast microcapsules as oral delivery systems, where highly branched (β1→6)-glucans lead to higher receptor affinity. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/32702 |
DOI: | 10.1016/j.carbpol.2021.118826 |
ISSN: | 0144-8617 |
Publisher Version: | https://www.sciencedirect.com/science/article/pii/S0144861721012133 |
Appears in Collections: | CICECO - Artigos DQ - Artigos REQUIMTE - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Bastos et al 2022 preproof.pdf | 1.28 MB | Adobe PDF | View/Open |
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