Please use this identifier to cite or link to this item:
|Brewer's yeast polysaccharides: a review of their exquisite structural features and biomedical applications
Oliveira, Patrícia G.
Gaspar, Vítor M.
Mano, João F.
Coimbra, Manuel A.
|Brewer’s spent yeast
|Recent advances on brewer’s yeast cell wall polysaccharides have unraveled exquisite structural features and diverse composition with (β1→3), (β1→6), (α1→4), (β1→4)- mix-linked glucans that are recognized to interact with different cell receptors and trigger specific biological responses. Herein, a comprehensive showcase of structurebiofunctional relationships between yeast polysaccharides and their biological targets is highlighted, with a focus on polysaccharide features that govern the biomedical activity. The insolubility of β-glucans is a crucial factor for binding and activation of Dectin-1 receptor, operating as adjuvants of immune responses. Contrarily, soluble low molecular weight β-glucans have a strong inhibition of reactive oxygen species production, acting as antagonists of Dectin-1 mediated signaling. Soluble glucan-protein moieties can also act as antitumoral agents. The balance between mannoproteins-TLR2 and β-glucans-Dectin-1 receptors-activation is crucial for osteogenesis. Biomedical applications value can also be obtained from yeast microcapsules as oral delivery systems, where highly branched (β1→6)-glucans lead to higher receptor affinity.
|Appears in Collections:
|CICECO - Artigos
DQ - Artigos
REQUIMTE - Artigos
Files in This Item:
|Bastos et al 2022 preproof.pdf
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.