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Title: Brewer's yeast polysaccharides: a review of their exquisite structural features and biomedical applications
Author: Bastos, Rita
Oliveira, Patrícia G.
Gaspar, Vítor M.
Mano, João F.
Coimbra, Manuel A.
Coelho, Elisabete
Keywords: Brewer’s spent yeast
Regenerative medicine
Drug delivery
Issue Date: 1-Feb-2022
Publisher: Elsevier
Abstract: Recent advances on brewer’s yeast cell wall polysaccharides have unraveled exquisite structural features and diverse composition with (β1→3), (β1→6), (α1→4), (β1→4)- mix-linked glucans that are recognized to interact with different cell receptors and trigger specific biological responses. Herein, a comprehensive showcase of structurebiofunctional relationships between yeast polysaccharides and their biological targets is highlighted, with a focus on polysaccharide features that govern the biomedical activity. The insolubility of β-glucans is a crucial factor for binding and activation of Dectin-1 receptor, operating as adjuvants of immune responses. Contrarily, soluble low molecular weight β-glucans have a strong inhibition of reactive oxygen species production, acting as antagonists of Dectin-1 mediated signaling. Soluble glucan-protein moieties can also act as antitumoral agents. The balance between mannoproteins-TLR2 and β-glucans-Dectin-1 receptors-activation is crucial for osteogenesis. Biomedical applications value can also be obtained from yeast microcapsules as oral delivery systems, where highly branched (β1→6)-glucans lead to higher receptor affinity.
Peer review: yes
DOI: 10.1016/j.carbpol.2021.118826
ISSN: 0144-8617
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Appears in Collections:CICECO - Artigos
DQ - Artigos
REQUIMTE - Artigos

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