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Title: Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation: systematic review and meta-analysis
Author: Mendes, Augusto J.
Pacheco-Barrios, Kevin
Lema, Alberto
Gonçalves, Óscar F.
Fregni, Felipe
Leite, Jorge
Carvalho, Sandra
Keywords: Event-related potential P3 P300
Working memory
Inhibitory control
Issue Date: 3-Nov-2021
Publisher: Elsevier
Abstract: Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go tasks, as well as during emotional processing. A total of 36 studies were identified, but only 23 were included in the quantitative analysis. The results show that the parietal P3 amplitude increased during oddball and n-back tasks, mostly after anodal stimulation over the left dorsolateral prefrontal cortex (p = 0.018, SMD = 0.4) and right inferior frontal gyrus (p < 0.001, SMD = 0.669) respectively. These findings suggest the potential usefulness of the parietal P3 ERP as a marker of tDCS-induced effects during task performance. Nonetheless, this study had a low number of studies and the presence of considerable risk of bias, highlighting issues to be addressed in the future.
Peer review: yes
DOI: 10.1016/j.neubiorev.2021.11.002
ISSN: 0149-7634
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Appears in Collections:DEP - Artigos

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