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http://hdl.handle.net/10773/32446
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DC Field | Value | Language |
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dc.contributor.author | Semitela, Ângela | pt_PT |
dc.contributor.author | Carvalho, Sara | pt_PT |
dc.contributor.author | Fernandes, Cristiana | pt_PT |
dc.contributor.author | Pinto, Susana | pt_PT |
dc.contributor.author | Fateixa, Sara | pt_PT |
dc.contributor.author | Nogueira, Helena I. S. | pt_PT |
dc.contributor.author | Bdikin, Igor | pt_PT |
dc.contributor.author | Completo, António | pt_PT |
dc.contributor.author | Marques, Paula A. A. P. | pt_PT |
dc.contributor.author | Gonçalves, Gil | pt_PT |
dc.date.accessioned | 2021-10-22T17:43:02Z | - |
dc.date.issued | 2021-10-05 | - |
dc.identifier.issn | 1616-5187 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/32446 | - |
dc.description.abstract | Biomimetics offers excellent prospects for design a novel generation of improved biomaterials. Here the controlled integration of graphene oxide (GO) derivatives with a 3D marine spongin (MS) network is explored to nanoengineer novel smart bio-based constructs for bone tissue engineering. The results point out that 3D MS surfaces can be homogeneously coated by layer-by-layer (LbL) assembly of oppositely charged polyethyleneimine (PEI) and GO. Notably, the GOPEI@MS bionanocomposites present a high structural and mechanical stability under compression tests in wet conditions (shape memory). Dynamic mechanically (2 h of sinusoidal compression cyclic interval (0.5 Hz, 0-10% strain)/14 d) stimulates GOPEI@MS seeded with osteoblast (MC3T3-E1), shows a significant improvement in bioactivity, with cell proliferation being two times higher than under static conditions. Besides, the dynamic assays show that GOPEI@MS bionanocomposites are able to act as mechanical stimulus-responsive scaffolds able to resemble physiological bone extracellular matrix (ECM) requirements by strongly triggering mineralization of the bone matrix. These results prove that the environment created by the system cell-GOPEI@MS is suitable for controlling the mechanisms regulating mechanical stimulation-induced cell proliferation for potential in vivo experimentation. | pt_PT |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (FCT) e Centro Portugal Regional Operational Programme (Centro 2020) | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Wiley | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F01913%2F2017%2FCP1459%2FCT0027/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F133129%2F2017/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00582%2F2015%2FCP1302%2FCT0019/PT | pt_PT |
dc.relation | REF-069-88-ARH-2018 | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00481%2F2020/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00481%2F2020/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT | pt_PT |
dc.relation | CENTRO-01-0145-FEDER-022083 | pt_PT |
dc.rights | embargoedAccess | pt_PT |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Bionanocomposites | pt_PT |
dc.subject | Spongin | pt_PT |
dc.subject | Graphene oxide | pt_PT |
dc.subject | Dynamic mechanical stimulation | pt_PT |
dc.subject | Bone-like extracellular matrix | pt_PT |
dc.title | Biomimetic graphene/spongin scaffolds for improved osteoblasts bioactivity via dynamic mechanical stimulation | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 1 | pt_PT |
degois.publication.lastPage | 12 | pt_PT |
degois.publication.title | Macromolecular bioscience | pt_PT |
dc.date.embargo | 2022-10-05 | - |
dc.identifier.doi | 10.1002/mabi.202100311 | pt_PT |
dc.identifier.essn | 1616-5195 | pt_PT |
dc.identifier.articlenumber | 2100311 | pt_PT |
Appears in Collections: | TEMA - Artigos CICECO - Artigos DEM - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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article-revised.docx | 11.08 MB | Microsoft Word XML | View/Open |
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