Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/32446
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dc.contributor.authorSemitela, Ângelapt_PT
dc.contributor.authorCarvalho, Sarapt_PT
dc.contributor.authorFernandes, Cristianapt_PT
dc.contributor.authorPinto, Susanapt_PT
dc.contributor.authorFateixa, Sarapt_PT
dc.contributor.authorNogueira, Helena I. S.pt_PT
dc.contributor.authorBdikin, Igorpt_PT
dc.contributor.authorCompleto, Antóniopt_PT
dc.contributor.authorMarques, Paula A. A. P.pt_PT
dc.contributor.authorGonçalves, Gilpt_PT
dc.date.accessioned2021-10-22T17:43:02Z-
dc.date.issued2021-10-05-
dc.identifier.issn1616-5187pt_PT
dc.identifier.urihttp://hdl.handle.net/10773/32446-
dc.description.abstractBiomimetics offers excellent prospects for design a novel generation of improved biomaterials. Here the controlled integration of graphene oxide (GO) derivatives with a 3D marine spongin (MS) network is explored to nanoengineer novel smart bio-based constructs for bone tissue engineering. The results point out that 3D MS surfaces can be homogeneously coated by layer-by-layer (LbL) assembly of oppositely charged polyethyleneimine (PEI) and GO. Notably, the GOPEI@MS bionanocomposites present a high structural and mechanical stability under compression tests in wet conditions (shape memory). Dynamic mechanically (2 h of sinusoidal compression cyclic interval (0.5 Hz, 0-10% strain)/14 d) stimulates GOPEI@MS seeded with osteoblast (MC3T3-E1), shows a significant improvement in bioactivity, with cell proliferation being two times higher than under static conditions. Besides, the dynamic assays show that GOPEI@MS bionanocomposites are able to act as mechanical stimulus-responsive scaffolds able to resemble physiological bone extracellular matrix (ECM) requirements by strongly triggering mineralization of the bone matrix. These results prove that the environment created by the system cell-GOPEI@MS is suitable for controlling the mechanisms regulating mechanical stimulation-induced cell proliferation for potential in vivo experimentation.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT) e Centro Portugal Regional Operational Programme (Centro 2020)pt_PT
dc.language.isoengpt_PT
dc.publisherWileypt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F01913%2F2017%2FCP1459%2FCT0027/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F133129%2F2017/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00582%2F2015%2FCP1302%2FCT0019/PTpt_PT
dc.relationREF-069-88-ARH-2018pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00481%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00481%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PTpt_PT
dc.relationCENTRO-01-0145-FEDER-022083pt_PT
dc.rightsembargoedAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBionanocompositespt_PT
dc.subjectSponginpt_PT
dc.subjectGraphene oxidept_PT
dc.subjectDynamic mechanical stimulationpt_PT
dc.subjectBone-like extracellular matrixpt_PT
dc.titleBiomimetic graphene/spongin scaffolds for improved osteoblasts bioactivity via dynamic mechanical stimulationpt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage12pt_PT
degois.publication.titleMacromolecular biosciencept_PT
dc.date.embargo2022-10-05-
dc.identifier.doi10.1002/mabi.202100311pt_PT
dc.identifier.essn1616-5195pt_PT
dc.identifier.articlenumber2100311pt_PT
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