Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/30235
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Morais, Eduarda S. | pt_PT |
dc.contributor.author | Silva, Nuno H. C. S. | pt_PT |
dc.contributor.author | Sintra, Tânia E. | pt_PT |
dc.contributor.author | Santos, Sónia A. O. | pt_PT |
dc.contributor.author | Neves, Bruno Miguel | pt_PT |
dc.contributor.author | Almeida, Isabel F. | pt_PT |
dc.contributor.author | Costa, Paulo C. | pt_PT |
dc.contributor.author | Correia-Sá, Inês | pt_PT |
dc.contributor.author | Ventura, Sónia P. M. | pt_PT |
dc.contributor.author | Silvestre, Armando J. D. | pt_PT |
dc.contributor.author | Freire, Mara G. | pt_PT |
dc.contributor.author | Freire, Carmen S. R. | pt_PT |
dc.date.accessioned | 2021-01-05T17:08:45Z | - |
dc.date.available | 2021-01-05T17:08:45Z | - |
dc.date.issued | 2019-02-15 | - |
dc.identifier.issn | 0144-8617 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/30235 | - |
dc.description.abstract | The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | SFRH/593 BD/85871/2012 | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F85690%2F2012/PT | pt_PT |
dc.relation | IF/01407/2012 | pt_PT |
dc.relation | IF/00402/2015 | pt_PT |
dc.relation | CENTRO-01-0145-FEDER-000001 | pt_PT |
dc.relation | ERC 2013-StG-337753 | pt_PT |
dc.rights | openAccess | pt_PT |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Antiinflammatory properties | pt_PT |
dc.subject | Antioxidant properties | pt_PT |
dc.subject | Bacterial celluloseIonic liquids | pt_PT |
dc.subject | Phenolic acids | pt_PT |
dc.subject | Skin treatment | pt_PT |
dc.subject | Topical applications | pt_PT |
dc.title | Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 187 | pt_PT |
degois.publication.lastPage | 197 | pt_PT |
degois.publication.title | Carbohydrate Polymers | pt_PT |
degois.publication.volume | 206 | pt_PT |
dc.identifier.doi | 10.1016/j.carbpol.2018.10.051 | pt_PT |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0144861718312402-main.pdf | 5.17 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.