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Title: Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
Author: Morais, Eduarda S.
Silva, Nuno H. C. S.
Sintra, Tânia E.
Santos, Sónia A. O.
Neves, Bruno Miguel
Almeida, Isabel F.
Costa, Paulo C.
Correia-Sá, Inês
Ventura, Sónia P. M.
Silvestre, Armando J. D.
Freire, Mara G.
Freire, Carmen S. R.
Keywords: Antiinflammatory properties
Antioxidant properties
Bacterial celluloseIonic liquids
Phenolic acids
Skin treatment
Topical applications
Issue Date: 15-Feb-2019
Publisher: Elsevier
Abstract: The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.
Peer review: yes
DOI: 10.1016/j.carbpol.2018.10.051
ISSN: 0144-8617
Appears in Collections:CICECO - Artigos

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