Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/29921
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dc.contributor.authorCastro, Leonor S.pt_PT
dc.contributor.authorPereira, Patríciapt_PT
dc.contributor.authorPassarinha, Luís A.pt_PT
dc.contributor.authorFreire, Mara G.pt_PT
dc.contributor.authorPedro, Augusto Q.pt_PT
dc.date.accessioned2020-11-27T17:47:10Z-
dc.date.available2020-11-27T17:47:10Z-
dc.date.issued2020-11-
dc.identifier.urihttp://hdl.handle.net/10773/29921-
dc.description.abstractBiopharmaceuticals are therapeutic drugs produced via biotechnological processes currently applied in the treatment of life-threatening diseases, representing a fast-growing area with an estimated market of $100 billion in 2017. Among these is interferon alfa 2b (IFNα-2b), a protein with significant antiviral and immunomodulatory activities currently applied in the treatment of oncological diseases. Although significant advances at the upstream level have been faced, current purification strategies are unable to cope with high product concentrations in a cost-effective approach. In this work, it was developed a cost-effective technology for the purification of IFNα-2b from Escherichia coli BL21 cultures, using polymer-polymer based aqueous biphasic systems (ABS) with ionic liquids (ILs) as adjuvants. Enhancements up to 3.5 in IFNα2b purification factors without affecting the IFNα2b structure were achieved in presence of ILs.pt_PT
dc.language.isoengpt_PT
dc.publisherUniversidade de Aveiropt_PT
dc.relationThe authors acknowledge the financial support from the project “IL2BioPro” - PTDC/BII-BBF/030840/2017- funded by FEDER, through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI), and by national funds (OE), through FCT/MCTES.pt_PT
dc.relationUIDB/50011/2020pt_PT
dc.relationUIDP/50011/2020pt_PT
dc.relationUIDB/00709/2020pt_PT
dc.relationUID/EMS/00285/2020pt_PT
dc.relationPTDC/BII-BBF/030840/2017pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiopharmaceuticalspt_PT
dc.subjectAqueous biphasic systemspt_PT
dc.subjectIonic liquidspt_PT
dc.subjectDownstream processingpt_PT
dc.titleA novel approach for the purification of biopharmaceuticals using polymer-based aqueous biphasic systems with ionic liquids as adjuvantspt_PT
dc.typeconferenceObjectpt_PT
dc.description.versionpublishedpt_PT
dc.peerreviewednopt_PT
ua.event.date19-20 November 2020pt_PT
degois.publication.titleJornadas CICECO 2020 - The future of science and ciceco: what have we learned from the pandemic?pt_PT
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