Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/29394
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dc.contributor.authorSantos, Franciscopt_PT
dc.contributor.authorMagalhães, Sandrapt_PT
dc.contributor.authorHenriques, Magda Carvalhopt_PT
dc.contributor.authorSilva, Beatrizpt_PT
dc.contributor.authorValença, Isabelpt_PT
dc.contributor.authorRibeiro, Danielapt_PT
dc.contributor.authorFardilha, Margaridapt_PT
dc.contributor.authorNunes, Alexandrapt_PT
dc.date.accessioned2020-10-09T16:01:18Z-
dc.date.available2020-10-09T16:01:18Z-
dc.date.issued2018-
dc.identifier.issn2213-235Xpt_PT
dc.identifier.urihttp://hdl.handle.net/10773/29394-
dc.description.abstractIntroduction: Prostate Cancer (PCa) is the second most common neoplasia in men. Because it is often diagnosed at a late stage, mortality rates remain high. Studying cancer metabolome, which reflects early changes that occur in cells, has gained relevance and may contribute to the identification of early diagnostic biomarkers and understanding tumor biology. Methods: Fourier-transform infrared (FTIR) spectroscopy is a metabolomics technique that probes the biochemical composition of the analyzed samples and allows to discriminate samples with distinct metabolic profiles, allowing the discrimination between cancerous and non-cancerous samples. In this study, FTIR spectra were acquired from PCa and normal prostate cell lines and analyzed by Principal Component Analysis (PCA). Results & Conclusion: Our results indicate a clear discrimination between the different cell lines, meaning at they exhibit distinct metabolic profiles. This discrimination can be attributed to an altered lipid metabolism (3000-2800 cm-1, 1800-1700 cm-1 and 1500-1400 cm-1) and changes in protein con-formation (1700-1600 cm-1). These results suggest that studying cancer metabolome with FTIR spec-troscopy not only allows the understanding of tumor metabolic behavior and may be useful to the de-velopment of new therapeutic targets.pt_PT
dc.language.isoengpt_PT
dc.publisherBentham Sciencept_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147343/PTpt_PT
dc.relationPOCI-01-0145-FEDER-007628pt_PT
dc.relationPOCI01-0145-FEDER-016728pt_PT
dc.relationPTDC/DTP-DES/6077/2014pt_PT
dc.relationSFRH/BD/131820/2017pt_PT
dc.relationSFRH/BD/131846/2017pt_PT
dc.relationSFRH/BD/101942/2014pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstate cancerpt_PT
dc.subjectCell linespt_PT
dc.subjectMetabolomicspt_PT
dc.subjectFTIRpt_PT
dc.subjectMetabolic profilept_PT
dc.subjectPrincipal component analysispt_PT
dc.titleUnderstanding prostate cancer cells metabolome: a spectroscopic approachpt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage218pt_PT
degois.publication.issue3pt_PT
degois.publication.lastPage224pt_PT
degois.publication.titleCurrent Metabolomicspt_PT
degois.publication.volume6pt_PT
dc.identifier.doi10.2174/2213235X07666181122124106pt_PT
dc.identifier.essn2213-2368pt_PT
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