Please use this identifier to cite or link to this item:
Title: One-pot intercalation strategy for the encapsulation of a CO-releasing organometallic molecule in a layered double hydroxide
Author: Calhau, Isabel B.
Gomes, Ana C.
Bruno, Sofia M.
Coelho, Ana C.
Magalhães, Clara I. R.
Romão, Carlos C.
Valente, Anabela A.
Gonçalves, Isabel S.
Pillinger, Martyn
Keywords: Molybdenum
Carbon monoxide
Isocyanide ligands
Drug delivery
Layered compounds
Issue Date: 31-Jul-2020
Publisher: Wiley-VCH Verlag
Abstract: The photoactivatable CO‐releasing molecule (photoCORM) [Mo(CO)3(CNCH2COOH)3] (ALF795) has been incorporated into a Zn,Al layered double hydroxide (LDH) host by a coprecipitation synthesis strategy. Powder X‐ray diffraction (PXRD) of the resultant material Zn,Al‐ALF795 showed that the ALF795 guest molecules assembled into a monolayer to give a basal spacing of 16.0 Å. FTIR and 13C{1H} CP MAS NMR spectroscopy confirmed that the molecular structure of the tricarbonyl complex was retained upon intercalation. Scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDS) and elemental analyses confirmed the phase‐purity of Zn,Al‐ALF795. The myoglobin assay was used to demonstrate that intercalated ALF795 retains the photoactive behavior of the free CORM, with a substantial fraction (42 %) of the high CO payload (2.46 mmol g–1) being released after exposure to UV light for 3 h under simulated physiological conditions. In addition, gas chromatography was used to track sequential light‐ and H2O2‐triggered decarbonylation of free and intercalated ALF795. In biological buffer solution (HEPES), less than 2 % Mo leaching from Zn,Al‐ALF795 took place after 5 h, showing the strong capacity of the LDH host to retain the unaltered complex and decarbonylation fragments.
Peer review: yes
DOI: 10.1002/ejic.202000202
ISSN: 1434-1948
Publisher Version:
Appears in Collections:CICECO - Artigos

Files in This Item:
File Description SizeFormat 
Postprint ejic.202000202.pdfPostprint version3.49 MBAdobe PDFView/Open

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.