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Title: Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
Author: Bjorge, Isabel M.
Choi, Insung S.
Correia, Clara R.
Mano, João F.
Keywords: Cell Differentiation
Issue Date: 21-Sep-2019
Publisher: Royal Society of Chemistry
Abstract: Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
Peer review: yes
DOI: 10.1039/c9nr06267j
ISSN: 2040-3364
Publisher Version:!divAbstract
Appears in Collections:CICECO - Artigos

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