Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/28509
Title: | Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation |
Author: | Bjorge, Isabel M. Choi, Insung S. Correia, Clara R. Mano, João F. |
Keywords: | Cell Differentiation Osteogenesis Microparticles Topography Bottom-up |
Issue Date: | 21-Sep-2019 |
Publisher: | Royal Society of Chemistry |
Abstract: | Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/28509 |
DOI: | 10.1039/c9nr06267j |
ISSN: | 2040-3364 |
Publisher Version: | https://pubs.rsc.org/--/content/articlelanding/2019/nr/c9nr06267j/unauth#!divAbstract |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
c9nr06267j.pdf | Manuscript | 1.65 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.