Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/27829
Title: | Endocrine Disrupting Chemicals in Patients with Chronic Obstructive Pulmonary Diseases |
Author: | Sousa, Ana Souto-Miranda, Sara Marques, Alda Valente, Carla Barros, Rafael Taborda-Barata, Luís Tanoue, Rumi Kunisue, Tatsuya Tanabe, Shinsuke Pastorinho, Ramiro |
Issue Date: | 18-Nov-2019 |
Abstract: | The study of indoor environmental quality as well as the development and progression of chronic respiratory diseases have received a great deal of attention in the past few years. However, most of those surveys focus on the effects of particulate matter (PM) and biological contaminants (fungi and bacteria) and evidences on the effects of endocrine disrupting chemicals (EDCs) in these pathologies are limited. Hence, RESPIRA project aims to contribute towards a better understanding of the role of multiple stressors in respiratory diseases by providing data on the levels and effects of EDCs in patients with Chronic Obstructive Pulmonary Disease (COPD) and control individuals from Estarreja region (NW Portugal). Here we will summarize the results obtained for phenolic compounds (parabens, triclosan and triclocarban) in matched human and indoor environmental samples (house dust) from COPD patients. Overall, the concentrations in dust samples are one to two orders of magnitude higher that the concentrations in human urine. Triclosan was detected in all the dust samples, triclocarban was detected in 82% of the dust samples and parabens in 90% to 100% of the samples. In urine samples, triclosan was detected in 56% of the samples, triclocarban was always bellow detection limit (0.25 ng/mL) and parabens detection frequency varied widely (23-84%). Interestingly, the highest level reported in dust for triclosan (1200 ng/g) corresponded to the house of the patient with the highest triclosan concentration in urine (140 ng/mL). |
Peer review: | no |
URI: | http://hdl.handle.net/10773/27829 |
ISBN: | 978-989-54470-3-9 |
Appears in Collections: | CICECO - Comunicações IBIMED - Comunicações Lab3R - Comunicações |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
2019_Sousa_Endocrine Disrupting Chemicals.pdf | 306.11 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.