Please use this identifier to cite or link to this item:
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Author: Butler, Geraldine
Rasmussen, Matthew D.
Lin, Michael F.
Santos, Manuel A. S.
Sakthikumar, Sharadha
Munro, Carol A.
Rheinbay, Esther
Grabherr, Manfred
Forche, Anja
Reedy, Jennifer L.
Agrafioti, Ino
Arnaud, Martha B.
Bates, Steven
Brown, Alistair J. P.
Brunke, Sascha
Costanzo, Maria C.
Fitzpatrick, David A.
Groot, Piet W. J. de
Harris, David
Hoyer, Lois L.
Hube, Bernhard
Klis, Frans M.
Kodira, Chinnappa
Lennard, Nicola
Logue, Mary E.
Martin, Ronny
Neiman, Aaron M.
Nikolaou, Elissavet
Quail, Michael A.
Quinn, Janet
Santos, Maria C.
Schmitzberger, Florian F.
Sherlock, Gavin
Shah, Prachi
Silverstein, Kevin A. T.
Skrzypek, Marek S.
Soll, David
Staggs, Rodney
Stansfield, Ian
Stumpf, Michael P. H.
Sudbery, Peter E.
Srikantha, Thyagarajan
Zeng, Qiandong
Berman, Judith
Berriman, Matthew
Heitman, Joseph
Gow, Neil A. R.
Lorenz, Michael C
Birren, Bruce W.
Kellis, Manolis
Cuomo, Christina A.
Keywords: Candida
Conserved sequence
Genes, Fungal
Genome, Fungal
Polymorphism, Genetic
Evolution, Molecular
Issue Date: 4-Jun-2009
Publisher: Nature Research
Abstract: Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
Peer review: yes
DOI: 10.1038/nature08064
ISSN: 0028-0836
Appears in Collections:CESAM - Artigos
DBio - Artigos

Files in This Item:
File Description SizeFormat 
nature08064.pdf548.52 kBAdobe PDFView/Open

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.